Tampa, FL Area Hurricane, Oct 1921

Damage to the pavilion in Safety Harbor Damage to a church under construction in New Port Richey Remains of Dr. Cyrus Teed's mausoleum on Estero Island

Initially, there were rumors and unconfirmed reports that Pass-a-Grille (today a neighborhood of St. Pete Beach) was wiped out and that up to 150 deaths occurred. Though the town was hit particularly hard, there were no fatalities and damage was less severe than indicated, reaching about $50,000. Storm surge was partially diverted to Boca Ciega Bay, but Pass-a-Grille generally suffered severe impact due to 5 to 7 ft (1.5 to 2.1 m) of water covering some areas. The hotel was extensively damaged, while its dancing pavilion was destroyed. A number of cottages were badly damaged. The storm destroyed a casino in Gulfport. The casino in Indian Rocks Beach collapsed after the sand foundation was washed away. In Largo, nearly all of the buildings at the Pinellas County Fairgrounds were rendered unusable.

In Clearwater, a number of buildings were severely damaged, including the ice and power plants, a theater, and a hotel. Many residences were also damaged. Electric and telephone wires were downed, leaving the city without power or telephone service. Boats were tossed about in the bay.The city of Oldsmar was devastated by storm surge, with portions of the town being inundated by 6 ft (1.8 m) of water. Many homes were practically demolished. Although no loss of human life occurred, many cattle drowned.

In Tarpon Springs, streets were littered with masses of debris. Sections of the city along the Anclote River were flooded. Primarily, impact consisted of structures being unroofed, windows shattering, and tree being uprooted. Throughout the city, electrical and telephone lines were downed, but telephone was partially maintained and electricity was restored quickly. Two hotels suffered extensive damage due to flooding. Although the high school was also severely damaged, classrooms remained usable. The cupola was torn away and the roof was partially damaged, including over the auditorium. The Odd Fellows Hall was thrown off its foundation and virtually destroyed. In the business district, most of the buildings leaked, resulting in damage to merchandise. Crop damage in Pinellas County was extensive, totaling about $1 million, which included a loss of 50%-70% of fruit lost and considerable damage to citrus trees.

The hurricane also brought extensive impact to portions of Pasco County. In New Port Richey, a few churches suffered severe damage or were destroyed. Nearly all walls collapsed and many windows were shattered at the school house. Only one shop remained standing at a plaza with several industrial stores. The vast majority of homes in the city received some degree of damage. Local crops experienced extensive impact, with a local farm losing about 800 boxes worth of fruit. Similar effects occurred in Port Richey. All stores received water damage, while two homes were destroyed and several others were inflicted with varying degrees of impact.

In Dade City, Mt. Zion Baptist Church was demolished, which was never rebuilt. Only the church cemetery remains. Another church, which opened early in the year, was nearly demolished by falling trees. A turpentine plant was damaged, including the loss of about one-third of the lumber stored in the building. The Sunnybrook Tobacco Company suffered significant impact, with nine large barns destroyed and about 110 acres (45 ha) of trees toppled. A number of other companies sustained damage, including the Dade City Packing Company and the Dade City Ice, Light and Power Company. Damage to the business reached $100,000. Several homes were damaged. Electrical, telegraph, and telephone wires were downed throughout the city. During the storm, electricity was maintained in the downtown section, while residential areas were left without power for two days. In San Antonio and Trilby, a number of buildings were moved off their foundations. The old city hall in Zephyrhills was moved about 4 ft (1.2 m). At a hotel, the building lost a portion of its roof and several windows were broken.[30] In addition, the hurricane virtually destroyed much of Passage Key, part of which was later rebuilt.

In Polk County, the storm left light property damage in Lakeland, reaching under $5,000, which included the school building being deroofed. Damage to crops was mostly limited to grapefruit and oranges, with losses estimated to have been less than 10%. In the rural communities outside Lakeland, several small building suffered damage. This was considered the worst tropical cyclone in the area since 1897.Lake County experienced sustained winds of 70 mph (110 km/h) and 12 to 15 in (300 to 380 mm) of rain in some areas. Much of the impact was confined to large trees being uprooted and ornamental vines suffering damage. A number of trees fell on electrical wires, causing power outages and disruptions to telephone service. Additionally, it is possible that a tornado touched down, based on some pine trees being "splintered from top to bottom and curled up like molasses candy." Damage to citrus crops was light, with losses conservatively estimated at less than 5%. Strong winds in Orange County left the entire city of Orlando without electricity, disrupting commerce. Citrus crops suffered no more than 5% in losses in the county. In St. Augustine, wind downed wires, some of which caused small fires in the business district. A steamship capsized between Jacksonville and Miami and there were reports of damage to several other small boats offshore. Agricultural damage from the hurricane was high, reaching over $2 million, with more than $1 million incurred to crops and the remainder to fertilizer and other materials. Citrus crops were especially hard hit, with 800,000 to 1,000,000 boxes of fruit lost. Salt water, caused by coastal flooding, prevented cultivation of soil in some areas, though rainfall eventually washed away the salt. In all, the hurricane left at least eight people dead and about $10 million in damage.