San Diego, CA Jet Liner and Small Aircraft Collide, Sep 1978

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Pacific Southwest Airlines (PSA) Flight 182 was a Boeing 727-214 commercial airliner, registration, N533PS that collided with a private Cessna 172 light aircraft, registration, N7711G over San Diego, California, around 9:00 am on Monday, September 25, 1978. It was Pacific Southwest Airlines' first accident involving fatalities. The death toll of 144 makes it the deadliest aircraft disaster in California history. Until the crash of American Airlines Flight 191, it was also the deadliest plane crash in U.S. aviation history.

Both aircraft crashed into North Park, a San Diego neighborhood, at the intersection of Dwight and Nile, killing all 137 people on both aircraft and seven people on the ground in houses, including two children. Nine others on the ground were injured and 22 homes were destroyed or damaged by the impact and debris.

The PSA 182 accident caused the revision of air traffic rules applicable to the busiest airports across the U.S., with the intention of improving separation of aircraft operating in the vicinity of large airports.

https://en.wikipedia.org/wiki/PSA_Flight_182